NeuroRegen 360 Protocol

An Integrated Protocol for Brain Recovery, Cognitive Health & Performance

Overview

The NeuroRegen 360 Protocol by LUMEA Wellness is a multidisciplinary, non-invasive brain health protocol that combines three complementary and clinically supported technologies:

• Repetitive Transcranial Magnetic Stimulation (rTMS)

• Photobiomodulation (PBM) via Red/NIR Light Helmet

• Hyperbaric Oxygen Therapy (HBOT)

This protocol is designed to enhance cognitive performance, accelerate neurorehabilitation, and support brain regeneration in individuals affected by neurodegenerative conditions, stroke, mild traumatic brain injury (mTBI), brain fog, burnout, or cognitive aging.

Its design is rooted in peer-reviewed scientific research and clinical evidence, making it a unique, effective solution for brain wellness, recovery, and neuroplasticity support.

Mechanisms of Action & Clinical Evidence

🧠 1. Repetitive Transcranial Magnetic Stimulation (rTMS)

Mechanism of Action:
rTMS delivers magnetic pulses to modulate cortical excitability, facilitating synaptic plasticity, neurogenesis, and functional brain network reorganization. High-frequency stimulation increases activity in underactive areas (e.g., left DLPFC in depression), while low-frequency suppresses overactivity (e.g., motor cortex in Parkinson’s).

Clinical Evidence:

• Stroke recovery: Randomized controlled trials (RCTs) show rTMS improves motor function, language, and post-stroke depression (Khedr et al., 2005; Zhang et al., 2017).

• Alzheimer’s disease: Multiple studies have demonstrated improved memory, attention, and executive function using rTMS over the dorsolateral prefrontal cortex (Bentwich et al., 2011; Rabey et al., 2013).

• Parkinson’s disease: Clinical trials show rTMS improves gait, motor symptoms, and quality of life, particularly when targeting the supplementary motor area (Shirota et al., 2013).

🔴 2. Photobiomodulation (Red Light Therapy Helmet)

Mechanism of Action:
PBM delivers red and near-infrared light to stimulate cytochrome c oxidase in mitochondria, increasing ATP production, reducing oxidative stress, and enhancing neuronal metabolism. It also improves regional cerebral blood flow and reduces glial inflammation.

Clinical Evidence:

• A 2019 clinical trial published in Photomedicine and Laser Surgery showed that PBM significantly improved cognitive function in patients with mild cognitive impairment (MCI) after 12 weeks of use.

• Naeser et al. (2011, 2014) demonstrated PBM’s benefits for chronic TBI patients, showing improvements in attention, executive function, and mood.

• Animal models and early human trials show PBM can reduce beta-amyloid burden, suggesting potential for use in Alzheimer’s management.

🌬️ 3. Hyperbaric Oxygen Therapy (HBOT)

Mechanism of Action:
HBOT involves breathing 100% oxygen in a pressurized chamber (1.3–2.0 ATA), drastically increasing plasma oxygen concentration. This promotes angiogenesis, mitochondrial function, stem cell activation, and neurogenesis, while reducing inflammation and apoptosis.

Clinical Evidence:

• A landmark study by Efrati et al. (2013) published in Neurobiology of Aging showed HBOT improved memory, attention, and information processing speed in post-stroke and mTBI patients, with accompanying structural brain changes seen on imaging.

• In 2020, Efrati’s group published a study in Aging demonstrating that HBOT can reverse cognitive decline and brain atrophy in aging adults, with measurable increases in CBF (cerebral blood flow) and brain perfusion.

• HBOT is now being studied for use in early Parkinson’s and Alzheimer’s with encouraging preliminary results in oxidative stress modulation and neuroinflammation reduction.

Expected Benefits of the NeuroRegen 360 Protocol

When administered consistently over 4–8 weeks, clients may experience:

• Improved short-term and working memory, processing speed, and focus

• Reduction in mental fatigue, brain fog, and sleep disturbances

• Enhanced mood stability, resilience, and stress adaptation

• Support in functional recovery post-stroke or TBI (motor, speech, cognition)

• Slowed progression of Alzheimer’s and Parkinson’s symptoms

• Improved executive functioning in older adults or high-performers

Effects tend to be cumulative, and may continue to improve even after sessions end, as the brain continues to remodel itself through neuroplasticity.

Protocol Structure

📅 Duration:

4 to 8 weeks, renewable for chronic conditions

🔁 Frequency:

3 to 5 sessions per week (based on clinical indication and resilience level)

⏱️ Session Breakdown (100 minutes):

1. Photobiomodulation Helmet (20 min)

   • Enhances neurovascular response

   • Reduces inflammation & primes the brain for stimulation

2. rTMS Session (20 min)

   • Custom-targeted protocol (motor cortex, DLPFC, SMA, etc.)

   • Activates or regulates specific brain circuits based on goals

3. Hyperbaric Oxygen Therapy (60 min)

   • Deep oxygenation and mitochondrial activation

   • Supports repair and reduces oxidative damage

🧬 Protocol Personalization

Conclusion

The NeuroRegen 360 Protocol is grounded in solid clinical research and offers a non-pharmacological, non-invasive solution for individuals seeking to repair, protect, or optimize their brain. By leveraging the synergistic power of rTMS, Red Light Therapy, and HBOT, this protocol helps unlock the brain’s innate capacity for regeneration, performance, and resilience.